Side Effects of Proton Beam Radiotherapy Treatment on Iris Melanoma


Tags RetinaUveitis
Journal Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

Ophthalmology Volume 130, Number 9, September 2023



該研究評估了質子束放射線治療(Proton Beam Radiotherapy, PBR)在處理虹膜黑色素瘤(Iris melanoma, IM)中的功能結果和副作用。該研究通過回顧性檢閱從2011年1月到2020年12月收集的數據進行。研究考慮了兩種類型的PBR:整個前部段PBR(whole anterior segment PBR, wPBR)和分段前部段PBR(segmenetal anterior segment PBR, sPBR)。



English Abstract

The study evaluates the functional outcomes and side effects of Proton Beam Radiotherapy (PBR) in treating Iris Melanoma (IM). The research was conducted as a retrospective review of data collected from January 2011 to December 2020. Two types of PBR were considered: Whole Anterior Segment PBR (wPBR) and Segmental Anterior Segment PBR (sPBR). Side effects were divided into ocular surface disease (OSD), secondary glaucoma,or cataract development.

The study found that PBR is a highly effective treatment for IM with a low recurrence rate (3patients: wPBR:1/51; sPBR:2/98). However, the side effects varied between the two types of PBR. The most common side effect in both groups was dry eye syndrome. Severe side effects like limbal stem cell failure and keratopathy were only found in the wPBR group. Secondary glaucoma was also more common in the wPBR group, and cataract development was observed in both groups but was higher in the wPBR group.

The study concludes that PBR is a successful treatment option for IM but recommends sPBR as the first treatment choice due to fewer severe side effects. Treatment with wPBR should be limited to cases with 360-degree angle involvement or diffuse iris surface seeding where sPBR would be insufficient. Further research is needed to understand the long-term impact of these treatments.