Ophthalmology Volume 130, Number 11, November 2023
本研究旨在評估高度近視患者中非青光眼性視神經萎縮（nonglaucomatous optic nerve atrophy (NGOA)的盛行率。研究納入俄羅斯烏拉爾眼科醫學調查中的5899名患者( 80.5% of 7328名適格個體)進行了評估。NGOA被分為5個任意階段(arbitrary stages)，其特徵包括網膜神經纖維層（retinal nerve fiber layer, RNFL）照片上的視線減弱(decreased visibility)、神經視網膜緣蒼白(neuroretinal rim pallo)r、網膜動脈直徑異常變薄(abnormally thin retinal arteriole diameter)以及由光學相干斷層掃描儀測定的網後神經維系膜異常變薄(abnormally thin peripapillary RNFL as measured by OCT)。研究中顯示高度近視患者中NGOA的盛行率為29.3％，具有NGOA的眼睛的平均程度為1.7個任意單位。此外，在研究中還觀察到，高度深度的近視可能與視野損失和中心視力下降有關，但這不能單純通過近視黃斑病變來解釋。因此，這項研究提供了有關高度近視及NGOA盛行率及其影響因素之相關信息。
This study aimed to determine the prevalence and factors associated with nonglaucomatous optic nerve atrophy (NGOA) in highly myopic individuals. Out of 116 highly myopic participants, 34 individuals (29.3%) were identified to have NGOA. The degree of NGOA was found to increase with longer axial length and wider temporal parapapillary gamma zone. The study highlighted the potential impact of NGOA on visual field and central visual acuity, particularly in highly myopic eyes. Additionally, the association between higher prevalence of NGOA and certain systemic parameters like systolic blood pressure was noted. While previous research has mainly focused on glaucomatous optic neuropathy, this study shed light on the prevalence and significance of NGOA in high myopia. Nonetheless, further follow-ups and investigations are needed to better understand the causes and potential therapeutic approaches for NGOA in highly myopic individuals.