Placebo Effect and Its Determinants in Ocular Hypotensive Therapy


Tags Glaucoma
Journal Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

Ophthalmology Volume 130, Number 11, November 2023



English Abstract

The text discusses the placebo effect in ocular hypotensive therapy for glaucoma treatment. The study aims to determine the effectiveness of the placebo in glaucoma treatment and the factors influencing its effect. The research used a meta-analysis approach with statistical pooling and multiple meta-regression analyses to explore the determinants of the placebo effect. Findings suggested that add-on study design and larger sample size were associated with a greater placebo effect, and there was no evidence of publication bias. Despite the extensive literature on placebo effects, this study is the first to systematically analyze the effect of placebo in ocular hypotensive therapy. The limitations of the study include a small number of untreated control trials and the use of study-level variables in the regression analysis. This study provides valuable insights into the placebo effect in ocular hypotensive therapy, emphasizing the need for further research to understand its clinical implications.