Ophthalmology Volume 130, Number 11, November 2023

中文摘要

本摘要旨在探討安慰劑對眼壓降低治療的潛在作用及影響因素。研究的主要結果是基於4週的治療所得到的效應值。通過統計分析選擇合適的元分析，並使用95%置信區間進行比較。多重元回歸模型被用來分析潛在的安慰劑效應決定因素。結果顯示，附加研究設計和較大樣本量與較大的安慰劑效應有關。研究還表明，在青光眼治療中，安慰劑效應可能引起免疫抑制反應，從而減少腎臟T細胞移植。然而，眼壓降低藥物中的安慰劑效應尚未量化，這使得對青光眼眼壓降低治療的有效性進行客觀和無偏見的結論變得困難。此外，本研究的結果還表明，安慰劑在降低眼壓方面的臨床效應超過未經治療。然而，本研究也存在一些限制，包括部分受試者對接受治療的態度不明確的影響因素等。因此，在評估眼壓降低治療的有效性和健康經濟分析以及樣本大小計算時，這一事實應該得到考慮。

English Abstract

The text discusses the placebo effect in ocular hypotensive therapy for glaucoma treatment. The study aims to determine the effectiveness of the placebo in glaucoma treatment and the factors influencing its effect. The research used a meta-analysis approach with statistical pooling and multiple meta-regression analyses to explore the determinants of the placebo effect. Findings suggested that add-on study design and larger sample size were associated with a greater placebo effect, and there was no evidence of publication bias. Despite the extensive literature on placebo effects, this study is the first to systematically analyze the effect of placebo in ocular hypotensive therapy. The limitations of the study include a small number of untreated control trials and the use of study-level variables in the regression analysis. This study provides valuable insights into the placebo effect in ocular hypotensive therapy, emphasizing the need for further research to understand its clinical implications.