Navigating Coronavirus Disease 2019 Vaccination and Uveitis: Identifying the Rates and Risk of Recurrent Uveitis after Coronavirus Disease Vaccination

中文摘要

這篇文章主要研究冠狀病毒疫苗接種後葡萄膜炎復發的比率和風險。來自奧克蘭區的炎性眼病登記病患被納入研究，研究者查詢他們的疫苗接種日期並進行了分析。結果發現，曾有復發病史、慢性葡萄膜炎患者以及病情穩定期較短的患者在接種疫苗後的復發風險最高。在接種疫苗後21至30天內，新出現的葡萄膜炎或復發的葡萄膜炎案例也有所增加，但由於大多數報告都是個案或小型病例系列，尚不清楚是否存在真實的相關性。在接種第一劑和第二劑疫苗後的兩個月以及接種第三劑疫苗後的六週，葡萄膜炎復發風險最高。研究結果證實，已知有葡萄膜炎病史的患者，接種疫苗後的復發風險比基線高出129%。最後，研究確認，無論是感染性還是非感染性葡萄膜炎，疫苗接種都與葡萄膜炎復發的風險增加有關。

English Abstract

This article investigates the rates and risks of recurrent uveitis following the COVID-19 vaccination. Subjects were drawn from the Inflammatory Eye Disease Registry in the Auckland District, and their vaccination dates were accessed and analyzed. The risk was found to be highest among those with previous recurrences, chronic uveitis, and a shorter period of quiescence. An increase in de novo uveitis or recurrence of uveitis within 21 to 30 days post-vaccination was observed, though due to the preponderance of individual cases or small case series, a definitive association is yet to be ascertained. The hazard of uveitis flare was highest at two months post-vaccination for the first and second doses and at six weeks after the third dose. The current study demonstrates an increased risk of uveitis flare after the first dose of COVID
vaccination. This risk was highest in those with previous recurrences, chronic uveitis, and shorter period of quiescence.