Impact of Age-Related Macular Degeneration and Related Visual Disability on the Risk of Depression
Ophthalmology Volume 130, Number 6, June 2023
This population-based cohort study aimed to evaluate the prospective association between age-related macular degeneration (AMD) and the development of depression. The study used nationwide clinical data from the Korean National Health Insurance Service and included 3,599,589 individuals over 50 years old. The results showed that AMD diagnosis was an independent risk factor for future depression development (Hazard ratio 1.15 ,95% CI, 1.13-1.17), with an increased risk observed in individuals with accompanying visual disability (HR 1.23, 95% CI, 1.16-1.30). The study highlights the need for early detection of depression in patients with AMD and emphasizes the importance of managing both the visual and mental health aspects of AMD patients. However, the study had limitations, including the use of claims data without imaging or survey-based verification of diseases. Further research is needed to understand the underlying mechanisms and to stratify patients based on the severity of vision loss and AMD type.