Impact of Age-Related Macular Degeneration and Related Visual Disability on the Risk of Depression

Ophthalmology Volume 130, Number 6, June 2023

中文摘要

這項基於人口的群體研究旨在評估年齡相關性黃斑部退化（AMD）與憂鬱發展之間的前瞻性關聯。該研究使用韓國國民健康保險服務的全國性臨床數據，包括3,599,589位50歲以上的個體。結果顯示，AMD診斷是未來憂鬱發展的獨立風險因素，伴隨視覺障礙的個體風險增加。該研究強調了在AMD患者中早期檢測憂鬱的需求，並強調了管理AMD患者的視覺和心理健康兩個方面的重要性。然而，該研究存在限制，包括僅使用索賠數據，無法進行影像或基於調查的疾病驗證。需要進一步研究來了解潛在機制，並根據視力損失的嚴重程度和AMD類型對患者進行分層。

English Abstract

This population-based cohort study aimed to evaluate the prospective association between age-related macular degeneration (AMD) and the development of depression. The study used nationwide clinical data from the Korean National Health Insurance Service and included 3,599,589 individuals over 50 years old. The results showed that AMD diagnosis was an independent risk factor for future depression development (Hazard ratio 1.15 ,95% CI, 1.13-1.17), with an increased risk observed in individuals with accompanying visual disability (HR 1.23, 95% CI, 1.16-1.30). The study highlights the need for early detection of depression in patients with AMD and emphasizes the importance of managing both the visual and mental health aspects of AMD patients. However, the study had limitations, including the use of claims data without imaging or survey-based verification of diseases. Further research is needed to understand the underlying mechanisms and to stratify patients based on the severity of vision loss and AMD type.