Fast Progressors in Glaucoma Prevalence Based on Global and Central Visual Field Loss

Ophthalmology Volume 130, Number 5, May 2023

中文摘要

這篇研究的目的是評估青光眼患者在視野測試中fast global and central field progression的患病率。研究人員收集了在澳大利亞、加州和紐約進行常規護理的青光眼患者的測試結果，發現約1/8的眼睛在global MD 值（< -1.0 dB/年）方面呈現快速進展(fast progression)，近1/3的眼睛在中央方面呈現 (-0.5 dB/年) 的衰退。研究發現突顯了評估中央視野損失進展的臨床重要性，並強調需要新的治療方法來預防快速進展的視功能障礙。

English Abstract

This study aimed to determine the prevalence of fast global and central visual field progression in individuals with glaucoma receiving routine care. The study included patients from a private ophthalmology clinic in Melbourne and participants who were examined as part of two prospective, longitudinal, observational studies of visual function and structural changes in glaucoma. All individuals had a diagnosis of glaucoma and had performed five or more reliable 24-2 VF tests over a 1- to 5-year period. The study found that approximately 1 in 8 eyes with glaucoma receiving routine care showed fast progression based on global MD values (< -1.0 dB/year), and nearly 1 in 3 eyes showed a < -0.5 dB/year decline centrally. These findings highlight the clinical importance of assessing progressive central VF loss and reinforce the need for new therapies to prevent functional disability in a notable proportion of individuals who continue to exhibit fast progression.