Assessment of Parafoveal Diabetic Macular Ischemia on Optical Coherence Tomography Angiography Images to Predict Diabetic Retinal Disease Progression and Visual Acuity Deterioration
| Created | |
|---|---|
| Tags | Retina |
| Journal | JAMA Ophthalmology |
| Status | 審查完成 |
| 校稿者 | 蕭靜熹 醫師 |
JAMA Ophthalmology Published online May 25, 2023
中文摘要
這項研究旨在研究糖尿病黃斑缺血（diabetic macula ischemia, DMI）在預測糖尿病視網膜病變（DR）進展、糖尿病性黃斑水腫（DME）發展和視力（VA）惡化的價值。研究人員使用基於光學相干斷層掃描血管影像學（OCTA）圖像的自動二值化(automated binary) DMI算法。他們使用深度學習算法分析了表層毛細血管網（superficial capillary plexus, SCP）和深層毛細血管網（deep capillary plexus, DCP）的OCTA圖像。
該研究納入了178名患者的321只眼睛。baseline SCP-DMI和DCP-DMI的存在與DR的進展顯著相關。在調整了各種因素後，DCP-DMI與DME的發展和視力惡化也有關聯。研究人員發現，SCP和DCP中都存在DMI可以改善對DR進展的預測判別能力。
該研究結論是，OCTA圖像中的DMI存在，特別是在DCP中，對於糖尿病患者的DR進展、DME發展和視力惡化具有預測價值
English Abstract
The study aimed to investigate the prognostic value of diabetic macular ischemia (DMI) in diabetic retinopathy (DR) progression, diabetic macular edema (DME) development, and visual acuity (VA) deterioration in patients with diabetes. The researchers used an automated binary DMI algorithm based on optical coherence tomography angiography (OCTA) images. They analyzed OCTA images of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using a deep learning algorithm.
The study included a total of 321 eyes from 178 patients. The presence of SCP-DMI and DCP-DMI at baseline was significantly associated with DR progression. DCP-DMI was also associated with DME development and VA deterioration after adjusting for various factors. The researchers found that the presence of DMI in both SCP and DCP improved the predictive discrimination for DR progression.
The study concluded that the presence of DMI on OCTA images, particularly in the DCP, provided prognostic value for DR progression, DME development, and VA deterioration in patients with diabetes.
