Vitamin D Supplementation and the Incidence of Cataract Surgery in Older Australian Adults

中文摘要

這份研究的目的是評估維生素D補充劑是否可以減少老年澳大利亞人的白內障手術發生率。研究是D-Health Trial的附屬研究，D-Health Trial是一項從2014年至2020年在澳大利亞進行的隨機、雙盲、安慰劑對照試驗，探討每月口服維生素D的療效。研究對象需排除高血鈣、高副甲狀腺素血症、腎結石、軟骨餘骨症或肺結節病等情況，以及每天攝取超過500 IU維生素D的人。總共隨機分配了21,315人，但有1,390人未達到此分析的資格標準，因此最終分析對象為19,925人。經過追蹤5年半，結果顯示每月口服60,000 IU維生素D3對白內障手術發生率沒有顯著影響，且與年齡、性別、身體質量指數、預測的血清25(OH)D濃度或環境紫外線輻射無關。本研究的發現意味著在維生素缺乏屬低盛行率的澳大利亞老年人群中，定期口服維生素D補充劑對減少白內障手術發生率沒有幫助。

English Abstract

The study aimed to investigate the potential role of vitamin D supplementation in reducing the incidence of cataract surgery in older Australian adults. The study was an ancillary analysis of the D-Health Trial, a randomized, double-masked, placebo-controlled trial of monthly vitamin D conducted from 2014 to 2020 within the Australian general population. A total of 19,925 participants were included, and the effect of vitamin D supplementation on the incidence of cataract surgery was assessed through linkage to universal health insurance records and hospital data. The results showed no evidence that monthly supplementation with 60,000 IU of vitamin D3 for up to 5 years reduced the incidence of cataract surgery. This finding was consistent across prespecified subgroup analyses, including people predicted to have low vitamin D status at baseline. The study suggests that the associations detected in observational studies may not be causal, and further research is needed to investigate the potential link between vitamin D and cataract.