Tumor-Associated Retinal Pigmentation in Choroidal Melanoma

中文摘要

本研究報告了一種先前未被認識的脈絡膜黑色素瘤臨床特徵，稱為腫瘤相關著色素素性視網膜（tumor-associated retinal pigmentation, TARP），並確定其與腫瘤生物學之間的相關性。研究結果發現，在較大的脈絡膜黑色素瘤中，TARP代表的是腫瘤相關巨噬細胞，而不是黑色素細胞。該研究還指出，輻射治療不需要涉及TARP區域，以減少輻射相關併發症的風險。這一新的臨床徵象似乎與高轉移風險的臨床和遺傳特徵(monosomy 3)的腫瘤有關。該研究的結果顯示，如果存在TARP，它可以被視為系統高風險著色素瘤的臨床生物標記。

English Abstract

The content discusses a previously unrecognized clinical feature of choroidal melanoma called tumor-associated retinal pigmentation (TARP). The study conducted at Liverpool Ocular Oncology Centre in the United Kingdom. TARP refers to the presence of tumor-associated macrophages within the intraretinal and subretinal spaces of larger choroidal melanomas. The study analyzed 20 choroidal melanomas and found that 18 of them had monosomy 3, a genetic abnormality associated with a high risk of metastasis. The presence of TARP seems to be linked to tumors with high metastatic-risk clinical and genetic characteristics. The study suggests that radiation treatments should not involve the TARP area to minimize complications. TARP may serve as a clinical biomarker for high-risk uveal melanoma lesions.