標籤存檔: Refraction

Efficacy and Safety of 0.01% and 0.02% Atropine for the Treatment of Pediatric Myopia Progression Over 3 Years

 

Created
Tags CGMHOPH Pediatric Refraction
Journal JAMA Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

JAMA Ophthalmology Published online June 1, 2023

中文摘要

這項研究旨在評估低劑量阿托品眼藥水在減緩兒童近視(近視)進展方面的療效和安全性。

以下是摘錄中提到的主要研究結果:

  • 該研究納入了576名參與者,並將其隨機分配到治療組。
  • 主要療效結果是在36個月時近視進展小於0.50屈光度的參與者比例。
  • 低劑量阿托品,具體濃度為0.01%和0.02%,與安慰劑進行比較。
  • 在36個月時,與安慰劑相比,低劑量阿托品0.01%顯著增加了反應者(近視進展較少的參與者)的比例,並減緩了球面等效屈光(SER)進展和軸向伸長(眼睛的加長)。
  • 低劑量阿托品0.02%在減緩軸向伸長方面具有益處,但並未顯著增加反應者比例或減緩SER進展。
  • 安全評估顯示,這兩種低劑量阿托品濃度都是安全且耐受良好的。
  • 研究結論是,特別是0.01%濃度的低劑量阿托品可能為兒童近視進展提供一種治療選擇。

重要的是要注意,這只是完整研究文章的一小部分,研究結果應該在完整研究的背景下進行解讀。為了獲得更詳細的信息和全面了解研究,建議閱讀完整的文章。

English Abstract

Place English abstract here

The study aimed to evaluate the efficacy and safety of low-dose atropine eye drops in slowing the progression of myopia (nearsightedness) in children.

Here are the key findings mentioned in the excerpt:

  • The study included 576 participants who were randomly assigned to treatment groups.
  • The primary efficacy outcome was the proportion of participants with less than 0.50 diopters of myopia progression at month 36.
  • Low-dose atropine, specifically at concentrations of 0.01% and 0.02%, was compared with a placebo.
  • At month 36, compared to the placebo, low-dose atropine 0.01% significantly increased the proportion of responders (participants with less myopia progression) and slowed mean spherical equivalent refractive (SER) progression and axial elongation (lengthening of the eye).
  • Low-dose atropine 0.02% showed benefit in slowing axial elongation but did not significantly increase the proportion of responders or slow SER progression.
  • Safety assessments indicated that both low-dose atropine concentrations were safe and well-tolerated.
  • The authors concluded that low-dose atropine, particularly at a concentration of 0.01%, may provide a treatment option for childhood myopia progression.

It’s important to note that this is only a small portion of the full research article, and the findings should be interpreted in the context of the complete study. For more detailed information and a comprehensive understanding of the research, it is recommended to read the full article.

Refractive Surgery Preferred Practice Pattern®

Refractive Surgery Preferred Practice Pattern®

Created
Tags CGMHOPH Cornea Refraction
Journal Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

Secretary for Quality of Care
Timothy W. Olsen, MD
Academy Staff
Andre Ambrus, MLIS
Meghan Daly
Flora C. Lum, MD
Medical Editor: Susan Garratt
Approved by: Board of Trustees
September 9, 2022
Copyright © 2022 American Academy of Ophthalmology®

English Summary :

Keratorefractive surgery can be used for a wide range of refractive errors, but intraocular procedures may be considered in some cases. A comprehensive medical eye evaluation should be performed before any refractive surgery procedure. Excimer laser ablation using wavefront aberrometry information can limit the induction of higher-order aberrations (HOAs) and even reduce pre-existing HOAs in some cases. The most common complaints from patients dissatisfied with refractive surgery include blurred vision, glare, dry eyes, and night-vision problems. Intraocular refractive surgery can be considered for patients who wish to reduce their dependence on eyeglasses or contact lenses. Potential complications of refractive lens exchange for myopia include retinal detachment, infectious endophthalmitis, intraoperative suprachoroidal hemorrhage, cystoid macular edema, corneal edema, and intraocular lens dislocation.

中文摘要:

角膜屈光手術可用於廣泛的屈光不正,但在某些情況下,可能會考慮使用眼內手術。在進行任何屈光手術之前,應對患者進行全面的眼科檢查評估。使用Excimer laser ablation using wavefront aberraometry可以限制高階像差(HOAs)的產生,並在某些情況下減少現有的HOAs。對屈光手術不滿意的患者最常見的抱怨包括視力模糊、眩光、眼睛乾燥和夜間視力問題。對於希望減少對眼鏡或隱形眼鏡依賴的患者,可以考慮進行眼內屈光手術。近視屈光晶狀體置換術的潛在併發症包括視網膜脫離、感染性眼內炎、手術中超脈絡膜出血、囊樣黃斑水腫、角膜水腫和人工晶狀體脫位。

HIGHLIGHTED FINDINGS AND RECOMMENDATIONS FOR CARE

Contraindications to refractive surgery include the following:

  • Unstable refraction
  • Abnormalities of the cornea (e.g., keratoconus or other corneal ectasias, thinning, edema, interstitial or neurotrophic keratitis, extensive vascularization)
  • Insufficient corneal thickness for the proposed ablation depth
  • Visually significant cataract
  • Uncontrolled glaucoma
  • Uncontrolled external disease (e.g., blepharitis, dry eye syndrome, atopy/allergy)
  • Uncontrolled autoimmune or other immune-mediated disease
  • Uncontrolled mental illness, including anxiety or depression
  • Unrealistic patient expectations

It is recommended that corneal refractive surgery patients be provided with a record listing diagnosis, preoperative keratometry readings, and refraction, as well as postoperative refraction.


It is recommended that the refractive surgeon maintain a record including preoperative keratometry and refraction as well as postoperative refraction and provide that data if needed for future eye care, including cataract surgery.


As part of the informed consent process, it is recommended that the refractive surgeon review common adverse effects such as dry eye and eventual presbyopia with patients considering corneal refractive surgery.


Excimer laser ablations that result in very thin residual stroma increase the risk for ectasia. For laser in situ keratomileusis (LASIK) procedures, a minimum of 250 µm is suggested as a safe residual stromal bed thickness. There is no absolute value that guarantees ectasia will not occur. Abnormal topography and percentage of tissue altered (PTA) higher or equal to 40% are also associated with higher ectasia risk.


Published studies have failed to demonstrate a relationship between pupil size and the quality of postop vision, minimizing the importance of pupillometry in the preoperative workup.
Persistent diffuse lamellar keratitis (DLK) unresponsive to corticosteroids should prompt consideration of microbial keratitis or interlamellar fluid due to increased intraocular pressure (IOP) measured peripheral to the LASIK flap, intraocular inflammation, or endothelial decompensation. For extensive DLK, the interface should be irrigated to minimize stromal loss and changes in refractive correction.


Surgical management of presbyopia includes keratorefractive surgery, corneal inlays, and intraocular lens implantation (multifocal, accommodative, and extended depth of focus lenses).

Refractive Errors Preferred Practice Pattern®

Refractive Errors Preferred Practice Pattern®

Created
Tags CGMHOPH Pediatric Refraction6
Journal Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

中文摘要

本文介紹了眼球屈光不正的相關問題及其治療方法。
眼球屈光不正是一種常見的視覺問題,包括近視、遠視和散光。
視力檢查和眼科檢查對於確定屈光不正的診斷和治療方案至關重要。矯正視力是診斷和治療眼球屈光不正的首要方法,以提高視力和減少不適感。選擇適合的眼鏡鏡框和鏡片對於矯正視力非常重要。
隱形眼鏡是另一種矯正視力的方法。在隱形眼鏡的選擇方面,應考慮患者的生活方式和需要。在安全和舒適性方面,目前的隱形眼鏡比過去有很大的改進。在選擇隱形眼鏡之前,應該進行完整的眼科檢查,以確定是否適合使用隱形眼鏡,以及適合哪種類型的隱形眼鏡。
在隱形眼鏡的使用中,適當的保養和清潔非常重要。不遵從隱形眼鏡的建議使用方法和保養方法,可能會導致角膜損傷和感染。在使用隱形眼鏡時,患者應注意眼睛是否有不適感,如灼熱、疼痛、視力模糊、紅斑和分泌物等。
有關角膜炎的研究顯示,Pseudomonas為使用隱形眼鏡相關的角膜炎最常見的病原體,而兒童的微生物性角膜炎風險相對較高。角膜炎風險增加的原因包括使用同一隱形眼鏡超過規定期限、隱形眼鏡清潔不當以及睡覺時未取出隱形眼鏡。在診斷和管理隱形眼鏡相關的問題時,醫護人員需要進行全面的眼科評估,包括評估患者的角膜和眼表,並詢問患者有無相關問題,例如眼睛紅腫、疼痛或異物感。
另一方面,鑑於許多人需要眼鏡或隱形眼鏡進行視力矯正,建議對於眼科醫生和患者,掌握當前的矯正方法以及各種矯正方法的適應症和禁忌症。
眼科醫生需要對不同人群的矯正方式進行全面的評估,包括患者的年齡、病史、角膜形態、視力問題的嚴重程度以及患者的職業和活動需求。例如,對於青少年和兒童,尤其是那些有近視風險的人,可以採用對抗近視進展的治療方法,如使用矯正光學和配戴角膜塑形鏡片等。
對於老年人或其他需要視力矯正的人,可以考慮使用多焦點鏡片或漸進式眼镜等多種矯正方法,以滿足他們不同距離的視力需求。此外,RGP lenses 是治療高度近視和高度散光的有效方法。需要指出的是,醫生在選擇矯正方法時應注意患者的眼睛健康和安全,以避免出現相關併發症。

English Abstract

This article discusses the related issues and treatment methods for refractive errors of the eye. Refractive errors of the eye are a common vision problem, including myopia, hyperopia, and astigmatism.

Vision and eye examinations are essential for determining the diagnosis and treatment plan for refractive errors. Correcting vision is the primary method for diagnosing and treating refractive errors of the eye, to improve vision and reduce discomfort. Choosing the appropriate eyeglass frames and lenses is critical for correcting vision.

Contact lenses are another method for correcting vision. In selecting contact lenses, patients’ lifestyles and needs should be considered. In terms of safety and comfort, current contact lenses have greatly improved compared to the past. Before selecting contact lenses, a complete eye examination should be conducted to determine if contact lenses are suitable and which type of contact lenses are appropriate.

Proper maintenance and cleaning are essential for contact lens use. Failure to follow the recommended usage and maintenance methods for contact lenses may lead to corneal damage and infection. When using contact lenses, patients should pay attention to any discomfort, such as burning, pain, blurred vision, redness, and discharge.

Research on keratitis shows that Pseudomonas is the most common pathogen associated with contact lens-related keratitis, and children are relatively more at risk for microbial keratitis. The reasons for increased risk of keratitis include using the same contact lenses beyond the prescribed time frame, improper contact lens cleaning, and failure to remove contact lenses while sleeping. When diagnosing and managing contact lens-related problems, healthcare professionals need to conduct a comprehensive eye assessment, including evaluating the patient’s cornea and ocular surface, and inquire about any relevant issues such as eye swelling, pain, or foreign body sensation.

On the other hand, considering that many people require glasses or contact lenses for vision correction, it is recommended for ophthalmologists and patients to be familiar with the current correction methods and the indications and contraindications for various correction methods. Ophthalmologists need to conduct a comprehensive evaluation of the correction methods for different populations, including the patient’s age, medical history, corneal morphology, severity of visual problems, and the patient’s occupation and activity needs. For example, for adolescents and children, especially those at risk for myopia, treatment methods to counteract myopia progression, such as using correcting optics, and wearing orthokeratology lenses, can be used.

For elderly individuals or others who require vision correction, various correction methods such as multifocal lenses or progressive eyeglasses can be considered to meet their visual needs at different distances. Additionally, rigid gas-permeable contact lenses are an effective method for treating highly myopic and highly astigmatic conditions. It should be noted that doctors should pay attention to patients’ eye health and safety when selecting correction methods to avoid related complications.

HIGHLIGHTED FINDINGS AND RECOMMENDATIONS FOR CARE

The prevalence of myopia is increasing in the United States and other industrialized societies. Increased time spent outdoors appears to be protective against myopia in children. Increased levels of near work are less of a risk factor than previously believed.


Increased outdoor time and low-concentration atropine have been shown to reduce the likelihood of myopia onset.


Antimuscarinic eyedrops, multifocal spectacles and contact lenses, and overnight orthokeratology have been shown to be varibly effective in some populations for myopia control, that is, to reduce the progression of myopia in school age children.


Studies from around the world have confirmed that that the incidence of microbial keratitis has not been reduced with the introduction of new lens types and that overnight wear of any contact lens is associated with a higher risk of infection than daily wear.


Although there are lenses approved by the FDA for extended wear, alternatives should be presented to patients for whom this mode of contact lens wear is being considered because overnight wear, regardless of contact lens type, increases risk of microbial keratitis.


Daily disposable contact lenses (rather than planned replacement lenses) are the safest lenses with the lowest rate of complications associated with soft contact lens wear. No-rub cleaning, topping off (reuse) of solutions, contaminated lens cases, exposure to tap water, wearing contact lenses in hot tubs and showers and while swimming, and changes in water supply are associated with Acanthamoeba and fungal keratitis related to contact lens wear in the recent decades.


Hydrogen peroxide systems are superior to multipurpose solutions for reducing the likelihood of infections or inflammatory complications; they are the preferred mode of nightly disinfection for patients who cannot wear daily disposable lenses, especially if they have had complications of contact lens wear in the past.


Presbyopia can be managed by using eyeglasses; contact lenses; topical agents; intraocular lenses with multifocal, accommodating, or extended depth of focus features; and monovision strategies with contact lenses or intraocular lenses. Adverse events related to FDA-approved drugs and devices should be reported to MedWatch
(www.fda.gov/medwatch)

Pediatric Eye Evaluations Preferred Practice Pattern®

Pediatric Eye Evaluations Preferred Practice Pattern®

Created
Tags CGMHOPH Pediatric Refraction
Journal Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

中文摘要

視力篩查通常在兒科診所由護士或其他受過培訓的醫護人員進行。兒童視力障礙和失明的原因在全球各地差異很大。在低收入國家,白內障和由傳染病或維生素A缺乏引起的角膜病變是導致嚴重視力障礙和失明的常見原因。

兒童應在整個童年和青少年時期接受定期視力篩查,因為隨著孩子的成長,可能會出現視力問題。大多數基於儀器的視力篩查方法可以檢測弱視的風險因素,如斜視、高度或不對稱的屈光不正、晶體混濁(如白內障)、視網膜異常(如視網膜母細胞瘤)和眼瞼下垂。在社區中,照相篩檢設備對弱視風險因素評估有高的敏感性和特異性。

執行視力篩查的醫生、護士、眼科醫生、驗光師、視光師、教師和其他執業人員應接受培訓,以便評估視力問題的風險因素、檢測眼睛結構性的問題、評估不同年齡兒童的視力,並/或進行儀器篩查。對於無法進行常規視力測試的兒童,應在6個月內(如有可能,更早)重新篩查或接受全面眼科檢查。

總之,對兒童和青少年進行定期視力篩查非常重要。

English Abstract

Vision screening is typically conducted in pediatric clinics by nurses or other trained healthcare professionals. The causes of severe vision impairment and blindness in children vary considerably worldwide, with cataracts and corneal conditions due to infectious diseases or vitamin A deficiency being common causes in low-income countries.

Children should undergo periodic vision screenings throughout childhood and adolescence, as vision problems may arise as they grow. Most instrument-based vision screening methods detect risk factors for amblyopia, such as strabismus, high or asymmetric refractive errors, media opacities (e.g., cataract), retinal abnormalities (e.g., retinoblastoma), and ptosis. In community settings, photoscreening devices demonstrate reasonably high sensitivity and specificity for amblyopia risk factors.

Physicians, nurses, ophthalmologists, optometrists, orthoptists, teachers, and other professionals performing vision screening should be trained to assess risk factors for vision problems, detect structural eye issues, evaluate visual abilities in children of different ages, and/or conduct instrument-based screenings. Children who are untestable should be rescreened within six months (preferably sooner) or referred for a comprehensive eye examination.

In summary, regular vision screenings for children and adolescents are essential in identifying and addressing potential vision problems to ensure healthy visual development.

HIGHLIGHTED RECOMMENDATIONS FOR CARE

Amblyopia meets the World Health Organization criteria for a disease that benefits from screening because it is an important health problem for which there is an accepted treatment, it has a recognizable latent or early symptomatic stage, and a suitable test or examination is available to diagnose it before permanent vision loss
occurs. The U.S. Preventive Services Task Force (USPSTF) recommends vision screening at least once for all children aged 3 to 5 years to detect amblyopia or its risk factors.

4 Vision testing with single optotypes is likely to overestimate visual acuity in a patient who has amblyopia. A more accurate assessment of monocular visual acuity is obtained by presenting a line of optotypes or a single optotype with crowding bars that surround (or crowd) the optotype being identified.
The choice and arrangement of optotypes (letters, numbers, symbols) on an eye chart can significantly affect the visual acuity score obtained. The preferred optotypes are LEA symbols, HOTV, and Sloan letters because they are standardized and validated.5, 6 Instrument-based screening techniques, such as photo screening and autorefraction, are useful for assessing amblyopia and reduced-vision risk factors for children ages 1 to 5 years, as this is a critical time for visual development.7 Instrument-based screening can also be used for older children who are unable to participate
in optotype-based screening. This type of screening has been shown to be useful in detecting amblyopia risk factors in children with developmental disabilities.8
Vision screening should be performed at an early age and at regular intervals throughout childhood to detect amblyopia risk factors and refractive errors. The elements of vision screening vary depending on the age and level of cooperation of the child, as shown in Table 1.

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Randomized Trial to Evaluate the Efficacy of the Nanodropper Device for Pupillary Dilation and Cycloplegia in Children

Randomized Trial to Evaluate the Efficacy of the Nanodropper Device for Pupillary Dilation and Cycloplegia in Children

Created
Tags CGMHOPH Pediatric,Refraction
Journal Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

Ophthalmology Volume 130, Number 3, March 2023

中文摘要

本研究旨在評估一種新型小容量滴眼器套件「Nanodropper」對於幼童瞳孔擴張和消除調節反應的有效性。本研究將患者分為兩組,隨機將小容量擴瞳滴眼液和標準滴眼液分別注入兩只眼睛,之後進行檢查,並以三個指標評估治療效果:spherical equivalent、瞳孔收縮百分比和散瞳後最大瞳孔直徑。結果顯示,使用「Nanodropper」治療組的最大瞳孔直徑達到非劣效,但瞳孔收縮百分比和spherical equivalent等效度在統計上沒有達到非劣效,但無臨床意義。本研究認為,小容量滴眼液具有減少不必要的醫療浪費和藥物毒性的潛力,且有效性與標準滴眼液相近。

English Abstract

The article discusses a study conducted at the Pediatric Ophthalmology Clinic of the University of California, San Francisco, which aimed to evaluate the effectiveness of small-volume eye drops for pediatric pupillary dilation and cycloplegia using the Nanodropper. Participants were randomized to receive small-volume dilating drops in one eye and standard of care dilating drops in the other eye. A non-inferiority analysis was performed to assess changes from before to after dilation in spherical equivalent, pupil constriction percentage, and maximum pupil diameter after dilation. The Nanodropper achieved non-inferiority for maximum pupil diameter after dilation, but not for spherical equivalent or constriction percentage. However, the small differences in the effect of the Nanodropper versus standard of care on all primary outcomes were not clinically significant. The study concludes that small-volume eye drops have the potential to decrease unnecessary medical waste and medication toxicity while maintaining therapeutic effect. The article notes that larger eye-drop volumes may increase the likelihood of adverse medication effects, especially because topical medications that reach the nasolacrimal duct and nasopharynx can be absorbed systemically through the mucosa, avoiding first-pass metabolism. The study demonstrates that small-volume eye drops are similar to standard of care eye drops for pupillary dilation and cycloplegia in pediatric patients. Using smaller-volume eye drops has economic and health care system advantages, as it could result in cost savings for patients, health care providers, and the medical system.

Longitudinal Changes and Predictive Value of Choroidal Thickness for Myopia Control after Repeated Low-Level Red-Light Therapy

3Longitudinal Changes and Predictive Value of Choroidal Thickness for Myopia Control after Repeated Low-Level Red-Light Therapy

Created
Tags CGMHOPH Pediatri,,Refraction
Journal Ophthalmology
Status 審查完成
校稿者 蕭靜熹 醫師

中文摘要

本篇研究報告指出,經過repeated low-level red-light (RLRL)治療1年後,近視兒童的視網膜脈絡膜厚度(mCT)有所改變,且此改變具有預測對於控制近視的治療效果的價值。該研究採用隨機對照試驗,比較RLRL與單視覺鏡片對於控制近視的效果,結果顯示RLRL治療相對於single-vision spectacle(單視覺鏡片)使用能夠減少69.4% axial elongation 和 76.6% spherical equivalent refraction progression。此外,該研究還證實RLRL治療可以促進mCT的增厚,這表明脈絡膜增加的血流可能是對控制近視效果的機制。然而,即使在至少75%的治療遵從度下,脈絡膜仍會變薄,原因仍需進一步研究。該研究建議,只需檢測3個月的mCT變化即可預測12個月的近視控制效果,並呼籲未來的研究應該進一步探討RLRL治療後脈絡膜增厚的機制。

English Abstract

This study aimed to evaluate longitudinal changes in macular choroidal thickness (mCT) in myopic children treated for one year with repeated low-level red-light (RLRL) therapy and their predictive value for treatment efficacy on myopia control. The study was a secondary analysis of data from a multicenter randomized controlled trial (RCT) evaluating the efficacy and safety of RLRL therapy on myopia control among Chinese children aged 8 to 13 years. The study found that RLRL induced sustained choroidal thickening over the full course of treatment, with macular choroidal thickness changes at 3 months alone being able to predict 12-month myopia control efficacy with reasonable accuracy. The study used fully automatic image segmentation with built-in software and only imaging after full cycloplegia to achieve high-quality mCT assessment. The predictive performance of 3-month mCT changes on myopia control efficacy was reliable, with retention rates in the RLRL group of 96.7% and 95.0% at 3- and 12-month follow-ups, respectively. The study concluded that early macular choroidal thickness changes after commencing RLRL therapy were significantly associated with myopia control efficacy at 12 months, and that mCT could be a potential biomarker of myopia. Further investigation is required to elucidate the mechanisms underlying choroidal thickening after RLRL therapy.