Ophthalmic Technology Assessment: Corneal Hysteresis for the Diagnosis of Glaucoma and Assessment of Progression Risk

Ophthalmology 2023;130:433-442 ª 2022 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology

中文摘要

該文章主要探討了角膜組織的“角膜遲滯”（corneal hysteresis，CH）測量對青光眼患者的診斷和治療的重要性。角膜遲滯是角膜在被壓平和恢復時壓力差異的度量，該測量具有較高的穩定性和良好的重複性，但其值會受到許多因素的影響，包括年齡、角膜厚度、眼軸長度和眼內壓力等。許多研究表明，青光眼患者的角膜遲滯值普遍較低，並且較低的值與青光眼的進展風險有關。一些研究還表明，即使在眼內壓力得到有效控制的情況下，角膜遲滯值較低的患者也面臨著較高的青光眼進展風險。因此，角膜遲滯測量可作為輔助診斷青光眼和預測患者疾病進展風險的一種工具。

English Abstract

The article discusses the importance of measuring corneal hysteresis (CH) in the diagnosis and management of glaucoma. CH refers to the difference in pressure readings between the inward and outward applanation of the cornea and is influenced by ocular biomechanical properties, such as tissue elasticity and thickness. Glaucoma patients typically have lower CH compared to healthy subjects, and lower CH is associated with an increased risk of glaucoma progression. The article also highlights the complexities and confounding factors involved in measuring CH, such as anisotropy, regional variations, and strain stiffening of ocular tissues. The authors review several studies that have investigated the relationship between CH and glaucoma, including cross-sectional and longitudinal studies, and suggest that clinical applications of CH measurement is a potential adjunct in identifying glaucoma patients and those at increased risk of disease progression. However, a causal relationship remains to be demonstrated.