Mendelian Randomization Implicates Bidirectional Association between Myopia and Primary Open-Angle Glaucoma or Intraocular Pressure
Mendelian Randomization Implicates Bidirectional Association between Myopia and Primary Open-Angle Glaucoma or Intraocular Pressure
| Created | |
|---|---|
| Tags | CGMHOPHGlaucoma |
| Journal | Ophthalmology |
| Status | 審查完成 |
| 校稿者 | 蕭靜熹 醫師 |
Ophthalmology 2023;130:394-403
中文摘要
本研究旨在利用Mendelian randomization (MR)分析解決外部混淆因素，確定近視、青光眼和相關特徵之間的遺傳因果關係。研究發現，眼壓對於refractive spherical equivalent 和原發性開角型青光眼 (POAG) 的影響最顯著（Sobel test，0.13; 95%信賴區間，0.09-0.17; P = 1.37 x10-8）。研究指出，近視和POAG之間存在著強烈的雙向遺傳因果關係，而眼壓是其主要中介因素。因此，本研究提出儘管臨床上在近視眼要做青光眼的診斷有些困難，但降低眼壓治療青光眼對近視眼可能有益。
English Abstract
The article discusses the use of Mendelian randomization (MR) analysis to investigate the causal relationship between myopia, primary open-angle glaucoma (POAG), and glaucoma-related traits, to overcome external confounders. The study used existing data from genome-wide association studies in White and Asian populations, and evaluated multiple statistical methods to address potential issues with assumptions and pleiotropy. The study found a bidirectional genetic causal link between myopia and POAG, primarily mediated by intraocular pressure (IOP). The findings suggest that IOP-lowering treatment for glaucoma may be beneficial in myopic eyes, despite challenges in diagnosis.
