Efficacy and Safety of 0.01% and 0.02% Atropine for the Treatment of Pediatric Myopia Progression Over 3 Years
| Created | |
|---|---|
| Tags | CGMHOPH Pediatric Refraction |
| Journal | JAMA Ophthalmology |
| Status | 審查完成 |
| 校稿者 | 蕭靜熹 醫師 |
JAMA Ophthalmology Published online June 1, 2023
中文摘要
這項研究旨在評估低劑量阿托品眼藥水在減緩兒童近視（近視）進展方面的療效和安全性。
以下是摘錄中提到的主要研究結果：
- 該研究納入了576名參與者，並將其隨機分配到治療組。
- 主要療效結果是在36個月時近視進展小於0.50屈光度的參與者比例。
- 低劑量阿托品，具體濃度為0.01%和0.02%，與安慰劑進行比較。
- 在36個月時，與安慰劑相比，低劑量阿托品0.01%顯著增加了反應者（近視進展較少的參與者）的比例，並減緩了球面等效屈光（SER）進展和軸向伸長（眼睛的加長）。
- 低劑量阿托品0.02%在減緩軸向伸長方面具有益處，但並未顯著增加反應者比例或減緩SER進展。
- 安全評估顯示，這兩種低劑量阿托品濃度都是安全且耐受良好的。
- 研究結論是，特別是0.01%濃度的低劑量阿托品可能為兒童近視進展提供一種治療選擇。
重要的是要注意，這只是完整研究文章的一小部分，研究結果應該在完整研究的背景下進行解讀。為了獲得更詳細的信息和全面了解研究，建議閱讀完整的文章。
English Abstract
Place English abstract here
The study aimed to evaluate the efficacy and safety of low-dose atropine eye drops in slowing the progression of myopia (nearsightedness) in children.
Here are the key findings mentioned in the excerpt:
- The study included 576 participants who were randomly assigned to treatment groups.
- The primary efficacy outcome was the proportion of participants with less than 0.50 diopters of myopia progression at month 36.
- Low-dose atropine, specifically at concentrations of 0.01% and 0.02%, was compared with a placebo.
- At month 36, compared to the placebo, low-dose atropine 0.01% significantly increased the proportion of responders (participants with less myopia progression) and slowed mean spherical equivalent refractive (SER) progression and axial elongation (lengthening of the eye).
- Low-dose atropine 0.02% showed benefit in slowing axial elongation but did not significantly increase the proportion of responders or slow SER progression.
- Safety assessments indicated that both low-dose atropine concentrations were safe and well-tolerated.
- The authors concluded that low-dose atropine, particularly at a concentration of 0.01%, may provide a treatment option for childhood myopia progression.
It’s important to note that this is only a small portion of the full research article, and the findings should be interpreted in the context of the complete study. For more detailed information and a comprehensive understanding of the research, it is recommended to read the full article.
