Associations between Serial Intravitreal Injections and Dry Eye

Ophthalmology Volume 130, Number 5, May 2023

中文摘要

本研究旨在探討anti-VEGF 治療neovascular AMD患者的連續IVI注射 對眼表和meibomian glands的影響。研究結果表明，相較於對側未注射眼，IVI治療tear break up time，角膜染色，Schirmer test osmolarity, meibomian gland expressibility and quality等數據均未有顯著差異，但可以減少MG流失，增加淚液體積，並減少炎症跡象。因此，這種治療方案可能對眼表有益影響。建議進一步研究IVI對眼表和MG的影響。

]English Abstract

The study aimed to investigate the effects of serial intravitreal injections on the ocular surface and meibomian glands in patients treated with anti-vascular endothelial growth factor for neovascular age-related macular degeneration. Ninety patients were included in the study, and there were no differences between treated and fellow eyes regarding various dry eye parameters. The study found that the repeated application of povidone-iodine could have antibacterial properties that can protect against ocular surface damage associated with dry eye disease. Contrary to expectations, the study revealed healthier values of various dry eye parameters including reduced MG loss, increased tear volume (tear meniscus height), and reduced signs of inflammation (bulbar redness) in eyes treated with IVI compared with the fellow untreated eyes. However, further investigations with prospective studies are warranted to support these findings and explore the mechanisms involved.