Risk of Dementia in Newly Diagnosed Glaucoma. A Nationwide Cohort Study in Korea

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韓國新診斷青光眼患者患痴呆症的風險：全國性群體研究

中文摘要

該文本是一項在韓國進行的全國性群體研究的簡要摘要，旨在調查新診斷青光眼患者患痴呆症的風險。研究人員使用韓國國家健康保險服務（NHIS）數據庫中的數據，該數據庫包含了整個人口的人口統計信息和醫療索賠數據。

以下是該研究的主要結果：

  1. 新診斷的青光眼患者患痴呆症，特別是阿茲海默病（Alzheimer’s disease, AD）的風險較高。青光眼患者發展痴呆症的風險比（HR）為1.89，表示風險增加。
  2. 即使在調整年齡、性別、體重指數（BMI）、收入、吸煙和飲酒狀況、視力、以及其他系統性共病如糖尿病、高血壓、中風和抑鬱症等多種混雜因素後，青光眼與痴呆症之間的關聯仍然顯著。
  3. 新診斷的青光眼與血管性痴呆（vascular dementia, VD）的風險沒有明顯關聯，但與阿茲海默病的風險顯著增加。
  4. 青光眼患者的痴呆風險在年齡較大的人群中較高，這表明與年齡相關的中樞神經系統（CNS）損傷和神經退行性疾病的易感性增加。

該研究強調了青光眼和痴呆症，尤其是阿茲海默病之間的潛在關聯，並且暗示了新診斷的青光眼患者患痴呆症的風險較高。然而，值得注意的是，該研究是在韓國進行的，需要進一步研究其他人群以驗證這些結果，並確定是否存在類似的關聯。

 

English Abstract

The given text is a brief summary of a nationwide cohort study conducted in South Korea to investigate the risk of dementia in individuals with newly diagnosed glaucoma. The researchers used data from the Korean National Health Insurance Service (NHIS) database, which contains demographic information and health claims data for the entire population.

Here are the key findings of the study:

  1. Participants with newly diagnosed glaucoma had a higher risk of developing dementia, particularly Alzheimer’s disease (AD). The hazard ratio (HR) for dementia development in individuals with glaucoma was 1.89, indicating an increased risk.
  2. The association between glaucoma and dementia remained significant even after adjusting for various confounding factors, including age, sex, body mass index (BMI), income, smoking and drinking status, visual acuity, and other systemic comorbidities such as diabetes, hypertension, stroke, and depression.
  3. The risk of vascular dementia (VD) was not significantly associated with newly diagnosed glaucoma, while the risk of AD was significantly higher in individuals with glaucoma.
  4. The risk of dementia was higher in older individuals with glaucoma, suggesting an age-related susceptibility to central nervous system (CNS) injury and neurodegeneration.

The study highlights the potential relationship between glaucoma and dementia, particularly AD, and suggests that individuals with newly diagnosed glaucoma may be at a higher risk of developing dementia. However, it’s important to note that this study was conducted in South Korea, and further research in other populations is needed to validate these findings and determine if similar associations exist.